Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamstersArticle Published on 2022-11-042022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] Antigen B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta block Community COVID-19 vaccine current Delta delta variant detectable Efficacy eliminating expressed Fever Gamma hamster immunization Lineage Lung pathology maintain Neutralizing antibody response omicron P.1 pandemic predominant Prevent PROTECT SARS-CoV-2 strains SARS-CoV-2 variant sequence Spread titre Transmission Vaccine variants variants of concern vectored vaccine virus VoC VOCs [DOI] 10.1038/s41467-022-34439-7 PMC 바로가기
ColdZyme® protects airway epithelia from infection with BA.4/5Article Published on 2022-10-312022-11-16 Journal: Respiratory Research [Category] COVID19(2023년), SARS, 변종, [키워드] Activation administration airway airway epithelia applied BA.4 BA.5 block blocked complement contagious Critical Culture epithelial in vitro data Infection Inflammation inflammatory reaction Intervention intrinsic omicron Pathogenesis prevented Prophylaxis PROTECT respiratory tissue SARS-CoV-2 SARS-CoV-2 transmission significantly subsequent Transmission variants variants of concern variants of concern. Viral transmission virus infection VoC VOCs while [DOI] 10.1186/s12931-022-02223-2 PMC 바로가기
Recombinant Protein Micelles to Block Transduction by SARS-CoV-2 PseudovirusArticle Published on 2022-10-252022-11-16 Journal: ACS Nano [Category] COVID19(2023년), SARS, 변종, [키워드] antibody Baker block Cell cloned Combination Concentration DAVID Delta delta variant E. coli expressing functional protein Genetic human cells Infection Laboratory micelle Mini-Proteins molecular multifunctional multivalent Multivalent Micelles N-terminus non-toxic Oleosin peptides performed Precision Protein Proteins receptor recombinant Recombinant protein reduced reducing S1 protein SARS-CoV-2 SARS-CoV-2 pseudovirus scattering Seattle Self-Assembly. the SARS-CoV-2 virus the Spike Therapies transduction variant wild-type [DOI] 10.1021/acsnano.2c09015 PMC 바로가기
Broad Tricyclic Ring Inhibitors Block SARS-CoV-2 Spike Function Required for Viral EntryArticle Published on 2022-10-142022-11-16 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 binding binding pocket block blocked broad inhibitor candidate cell-cell fusion cellular circulating SARS-CoV-2 variant Compound conformational change conserved coronavirus Critical Entry inhibitor entry inhibitors entry pathway facilitate function glycoprotein host cell Infection inhibitory effect interfere mode of action plasma membrane receptor Receptor binding domain required Ring SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike selective significantly Small molecules spike Spike. subsequent tested the SARS-CoV-2 these compound Tricyclic Trigger viral entry viral spike [DOI] 10.1021/acsinfecdis.1c00658 PMC 바로가기
LRRC15 inhibits SARS-CoV-2 cellular entry in transArticle Published on 2022-10-132022-11-16 Journal: PLoS Biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 Activation angiotensin-converting enzyme 2 bind block Cell cell type cellular entry coexpressed coronavirus 2 COVID-19 patients CRISPR dataset entry receptor expression Factor fibroblast human lung Infection inhibit inhibiting inhibitory LRRC15 lung moderate physiological protective role RBD regulate respiratory reveal SARS-CoV-2 SARS-CoV-2 entry Single-cell RNA sequencing Spike protein the receptor-binding domain viral entry [DOI] 10.1371/journal.pbio.3001805 PMC 바로가기
A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA VirusesArticle Published on 2022-10-062022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Antiviral antivirals bind block cellular membrane Chikungunya CHIKV coronavirus dependent on develop domain endosomal endosomal entry Factor flavivirus Host HPV Infection inhibit inhibitor Interaction Panel peptide Peptide inhibitor Protein protein trafficking provide reduced regulate replicate RNA RNA viruses SARS-CoV-2 shown syntenin. target targeting virus [DOI] 10.3390/v14102202 PMC 바로가기
Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2Article Published on 2022-10-012022-11-16 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome addition Analysis binding affinity block Calu-3 caused cell entry complementary coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients docking drug energy transfer evade exhibit Fritillaria functional glycoprotein Hydrogen bond Infection inhibit inhibit SARS-CoV-2 inhibitor Interaction lung cells molecular docking analysis N501Y patients peimine. Protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 viral infection significantly small molecule suggested suppresse the spike protein treatment for COVID-19 Vaccine variant variant spike variants of concern variants of SARS-CoV-2 viral entry viral infection viral infections viral spike viral spike protein VoC VOCs [DOI] 10.1111/jfbc.14354 PMC 바로가기
Spatial- and Valence-Matched Neutralizing DNA Nanostructure Blocks Wild-Type SARS-CoV-2 and Omicron Variant InfectionArticle Published on 2022-09-272022-11-15 Journal: ACS Nano [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] addition binding affinity block Cell Characteristics complementary conformational DNA DNA nanotechnology DNA nanotechnology. event Infection infection mechanism inhibit inhibiting Interaction majority Mutant strains nanostructure natural Neutralizing Neutralizing activity Neutralizing antibodies neutralizing aptamer omicron Pathogens Precision Prevent provide SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 spike trimer spatial-patterned interaction spike trimer target trimer variant [DOI] 10.1021/acsnano.2c06803 PMC 바로가기
Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variantsArticle Published on 2022-09-142022-11-16 Journal: PLoS ONE [Category] SARS, 변종, [키워드] 2X-121 50% effective concentration ADP-ribose affecting Alpha antiviral drug B.1.1.7 B.1.351 B.1.617.2 block cellular Combination EC50 Effect estimate experiment greater Host in vitro inhibit inhibitor mechanism P.1 PARP PARPs pathway polymerase Remdesivir replication of SARS-CoV-2 SARS-CoV-2 stenoparib variant viral replication wild type [DOI] 10.1371/journal.pone.0272916 PMC 바로가기
UV-C Light Completely Blocks Aerosol Transmission of Highly Contagious SARS-CoV-2 Variants WA1 and Delta in HamstersArticle Published on 2022-09-062022-11-16 Journal: Environmental science & technology [Category] SARS, 변종, [키워드] activities adhere aerosol block COVID COVID19 Delta effective Effectiveness element hamster individual investigated LIGHT measure Population Prevent prevented reduce risk SARS-CoV-2 SARS-CoV-2 transmission Spread susceptible Syrian Golden hamsters Transmission transmission of SARS-CoV-2 Transmission. ultraviolet light UV-C virus WA1 wavelength [DOI] 10.1021/acs.est.2c02822 PMC 바로가기